Targeting the Canonical WNT Signalling Pathway to Promote Central Nervous System Remyelination in Vivo

Grant number: 1111041 | Funding period: 2016 - 2019

Completed

Abstract

Multiple Sclerosis (MS) occurs when immune cells attack the sheaths, called myelin, that cover and protect nerve connections. If myelin is damaged nerve cells cannot function properly, leading to severe disability. The brain has a group of cells that could potentially replace damaged myelin, but as MS worsens these cells are blocked in a state where they cannot help in repair. I will remove a signal specifically from these cells and determine if this unblocks them resulting myelin repair.

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Imaging and Quantification of Myelin Integrity After Injury With Spectral Confocal Reflectance Microscopy

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Developing a high-throughput approach to quantify the extent of myelin integrity in preclinical models of demyelinating diseases w..

Activity-dependent central nervous system myelination throughout life

O de Faria, DG Gonsalvez, M Nicholson, J Xiao

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Myelin, the multilayered membrane surrounding many axons in the nervous system, increases the speed by which electrical signals tr..

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David Gonsalvez, Georgina Craig, Darragh Walsh, Barry Hughes, Rhiannon Wood, Sang Won Yoo, Simon Murray, Junhua Xiao

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Murine oligodendrocyte generation dynamics are considered distinct from those in the human, with implications for cross-species di..

University of Melbourne Researchers

David Gonsalvez